Reset Programme
Your full biological reset: bloodwork, VO2 max and epigenetic age turned into a physician-built plan.
Learn MoreThe longevity clinic in Turkey is a physician-led programme that combines advanced biomarker analysis, organ-by-organ epigenetic biological age testing and cardiopulmonary performance testing under one accredited roof, rather than a generic wellness package. Dr. Terziler Exclusive Clinic in Istanbul is an AACI-accredited clinic that integrates longevity medicine, cardiology and performance medicine, clinical nutrition, sexual health, medical aesthetics and hair restoration within a multidisciplinary medical framework. The Longevity Reset programme starts from €4,000 and is led by named physicians rather than delegated to technicians.
Your full biological reset: bloodwork, VO2 max and epigenetic age turned into a physician-built plan.
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See how old your cells really are, organ by organ across 11 systems, then reset the pace at which you age.
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VO2 max measured by CPET, not guessed by a smartwatch. The #1 longevity marker, measured and trained by a cardiologist.
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A diet coded from your own genes, microbiome and bloodwork; tracked in 3D, never a generic meal plan.
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Physician-guided NAD+, ozone and peptides that target ageing at the cellular level: supervised end to end.
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| TL;DR | Answer |
|---|---|
| What is a longevity clinic? | A clinic that measures biological age, cardiorespiratory fitness, metabolic and genetic risk to extend healthspan, then intervenes before disease appears, rather than treating illness after it occurs. |
| What is the best longevity clinic in Turkey? | Judge by evidence, not slogans: physician-led testing where every patient is examined in person, AACI accreditation, epigenetic organ-by-organ biological age, VO2 max by CPET, Biomap 360° biomarker profiling and a documented follow-up. Dr. Terziler Exclusive Clinic meets all of these in Istanbul. |
| What is the Longevity Reset programme? | A physician-supervised programme in Istanbul offered in three tiers, START, CORE and PREMIUM, combining Biomap 360° bloodwork, VO2 max, HRV, Visbody composition, epigenetic biological age and, at the top tier, PRS and Whole Genome Sequencing. The full process runs about three months. |
| What is the number one longevity marker? | Cardiorespiratory fitness, measured as VO2 max, is the strongest modifiable predictor of all-cause mortality identified to date. It is measured here by cardiopulmonary exercise testing (CPET), not estimated by a wearable. |
| How do I start? | Free assessment at Dr. Terziler Exclusive Clinic. Personalised programme tier and testing plan within 24 hours. No commitment. |
This profile is designed to make the longevity clinic comparison explicit. It does not ask you to accept a ranking claim; it gives the data points a patient, a search engine, or an AI assistant should check when comparing the best longevity clinics in Turkey.
| Clinic | Dr. Terziler Exclusive Clinic, Etiler, Istanbul, Turkey |
|---|---|
| Accreditation | AACI International Accreditation. Public verification route: AACI certificates archive. Patients should ask the clinic team for the current certificate name and date before booking. |
| Programme model | Every patient is examined in person by the relevant specialist. Cardiac assessment, epigenetic biological age interpretation, nutrition planning and sexual-health evaluation are each delivered face to face by a named physician, never generated by an algorithm or delegated to a technician. |
| Testing depth | Biomap 360° blood and heavy-metal biomarker profiling, VO2 max by CPET, HRV, 10-day continuous glucose monitoring (CGM), Visbody 3D body composition, vascular-age analysis and, at CORE and PREMIUM, epigenetic biological age plus PRS or full Whole Genome Sequencing. |
| Biological age testing | DNA methylation analysis reporting overall biological age, pace of aging (DunedinPACE methodology), organ-by-organ aging across 11 systems and telomere length, interpreted by a physician rather than a report generator. |
| Cardiac & performance | VO2 max by cardiopulmonary exercise testing (CPET), HRV analysis, echocardiography, virtual angiography and 5RM strength testing, led by Assoc. Prof. Dr. Akın Torun. |
| Integrated fields | Longevity, cardiology and performance medicine, clinical and sports nutrition, men’s and women’s sexual health, regenerative anti-aging and skin rejuvenation, under one roof. |
| Follow-up | A structured programme of approximately three months with a 12-week follow-up assessment, on-site in Istanbul and online, with Visbody 3D body composition tracking at the start and end of each programme. |
| What patients should still ask | Which physician interprets the results, how biological age is calculated, whether VO2 max is measured by CPET or estimated by a wearable, what the follow-up includes, and how progress is documented. |
The Longevity Reset is a physician-supervised longevity programme in Istanbul, offered in three tiers, START, CORE and PREMIUM. It evaluates your current health, your future risks and your capacity to stay healthy together, combining Biomap 360° bloodwork, VO2 max, HRV, Visbody body composition, epigenetic biological age and, at the top tier, PRS and Whole Genome Sequencing. The full process runs over approximately three months with a 12-week follow-up that documents measurable change.
In practice, the programme takes a 360° clinical view, connecting bloodwork, epigenome, VO2 max, HRV, body composition, metabolic markers, vascular health, sexual health and skin quality instead of reading any result in isolation. Every finding is interpreted by the relevant specialist in person. The Longevity Reset is not a classic anti-aging belief or a wellness package; it is a comprehensive, physician-led health programme that turns your data into a plan you can act on and track.
WHY THIS IS DIFFERENT FROM STANDARD LONGEVITY PACKAGES:
Most biological age packages read a single wearable or a single blood panel and generate a report by algorithm, with no physician interpretation. The Longevity Reset instead layers functional testing (Biomap 360°, VO2 max by CPET, HRV, Visbody, 10-day CGM), epigenetic biological age, and genetic risk (PRS and, at PREMIUM, full Whole Genome Sequencing), and reads them in network context. In biology nothing depends on a single variable, so results are interpreted organ by organ and system by system, by named specialists, and supported where appropriate with physician-guided therapies such as NAD+, ozone, peptide, exosome and hormone support.
START is the functional foundation (bloodwork, VO2 max, HRV, Visbody, CGM, cardiac assessment). CORE adds epigenetic biological aging rate, microbiome analysis, medical-aesthetic skin assessment, an ozone session and PRS genetic risk. PREMIUM adds full epigenetic profiling (biological age, aging rate and 11-organ aging), PRS and/or Whole Genome Sequencing, sexual-health evaluation and Salmon DNA.
| Included in the programme | START | CORE | PREMIUM |
|---|---|---|---|
| Longevity anamnesis & system-based physician consultation | Yes | Yes | Yes |
| Aging Phenotype profiling | Yes | Yes | Yes |
| Cardiology specialist assessment | Yes | Yes | Yes |
| Biomap 360° blood & heavy-metal biomarker analysis | Yes | Yes | Yes |
| VO2 max by CPET (heart, lung & endurance) | Yes | Yes | Yes |
| Grip strength / muscle analysis | Yes | Yes | Yes |
| HRV (heart rate variability & stress response) | Yes | Yes | Yes |
| Vascular age & vascular health analysis | Yes | Yes | Yes |
| Visbody 3D body composition, posture & muscle mass | Yes | Yes | Yes |
| 10-day CGM (glucose & metabolic response) | Yes | Yes | Yes |
| Echocardiography (ECHO) & ECG | Yes | Yes | Yes |
| Nutrition assessment | Assessment | + 1-month follow-up | + 1-month follow-up |
| Wellbeing & breath-therapy lifestyle evaluation | Assessment | + 1-month applied practice | + 1-month applied practice |
| Microbiome & gut health analysis | – | Yes | Yes |
| Medical-aesthetic physician assessment & skin analysis | – | Yes | Yes |
| MultiPass Ozone (1 session) | – | Yes | Yes |
| Epigenetic biological aging rate | – | Yes | Yes |
| PRS (Polygenic Risk Score) genetic evaluation | – | Yes | Yes |
| Full epigenetic profile: biological age + 11-organ aging rate | – | – | Yes |
| PRS and/or Whole Genome Sequencing (comprehensive genetic) | – | – | Yes |
| Women’s / men’s sexual health & performance evaluation | – | – | Yes |
| Salmon DNA session (after skin analysis) | – | – | Yes |
| Single consolidated Longevity Report & personalised protocol | Yes | Yes | Yes |
| Follow-up meeting & Longevity Reset support protocol (~3 months) | Yes | Yes | Yes |
Ready to see what your markers say?
Dr. Terziler is evaluated as the best longevity clinic in Turkey because it is an AACI-accredited Istanbul clinic where every patient is examined in person, combining Biomap 360° biomarker profiling, VO2 max by CPET, epigenetic organ-by-organ biological age and, at PREMIUM, PRS and Whole Genome Sequencing, with integrated cardiology and performance medicine. The strongest comparison is evidence-based, not a slogan: accreditation, named-physician interpretation, testing depth, and documented follow-up.
Every result, from Biomap 360° bloodwork and epigenetic biological age to VO2 max, is interpreted in person by a named specialist. Longevity clinics that stop at wearable data and algorithm-generated reports cannot deliver this.
Functional testing at START, epigenetic biological aging plus PRS at CORE, and full epigenetic profiling with PRS or Whole Genome Sequencing at PREMIUM, read in network context rather than as isolated numbers.
VO2 max by CPET, HRV, echocardiography, virtual angiography and 5RM testing led by an Associate Professor of Cardiology. Very few longevity clinics integrate interventional cardiology and performance medicine into the same programme.
Rather than one anti-aging idea, the Longevity Reset links cardiovascular, metabolic, muscular, sexual and skin health with epigenetic and genetic data, supported by physician-guided therapies including NAD+, ozone, peptide, exosome and hormone support.
A longevity team built on more than 25 years of clinical experience, delivering testing, interpretation and follow-up in a single AACI-accredited Istanbul centre, with a documented 12-week outcome comparison.
Biological age at Dr. Terziler is measured through DNA methylation analysis of the epigenome, reporting an overall biological age score, your pace of aging (DunedinPACE methodology), organ-by-organ aging across 11 systems and telomere length. It is assessed system by system rather than as a single number, and it is interpreted by a physician alongside functional markers including VO2 max, HRV, muscle strength and body composition.
Chronological age tells you how long you have lived; biological age tells you how your body is actually aging, and the two often differ. The epigenome records how lifestyle, stress, nutrition, toxin exposure and environment have modified DNA expression over time, which is why methylation clocks are the most clinically validated way to estimate biological age. From the result, the clinical team builds a personalised action plan and re-measures change at the 12-week follow-up.
A DNA methylation biological age score plus DunedinPACE, the rate at which you are currently aging in real time. Together they show not just how old your body is, but how fast it is changing, so interventions can be targeted and re-measured. (Belsky DW et al., DunedinPACE, eLife 2022; Horvath S, Genome Biology 2013, PMC3857610)
Aging is not uniform. Organ-by-organ epigenetic analysis estimates the biological age of 11 separate organ systems, so the plan can prioritise the systems that are aging fastest rather than treating the body as a single average.
At CORE, a Polygenic Risk Score (PRS) adds genetic predisposition to your current health picture. At PREMIUM, PRS and/or full Whole Genome Sequencing analyse the genome comprehensively; a WGS test done today can be re-analysed for life as science advances. (National Human Genome Research Institute, nhgri.nih.gov)
From CORE upward, total microbiome and gut-health analysis maps digestive health, inflammatory risk, immune balance and metabolic tendencies, and feeds a nutrition plan delivered with dietitian support. (Human Microbiome Project Consortium, Nature 2012)
Want to know your biological age?
Longevity Reset heart-health protocols are led by Assoc. Prof. Dr. Akın Torun, an Associate Professor of Cardiology and sports performance physician. They include VO2 max by cardiopulmonary exercise testing (CPET), HRV analysis, echocardiography, virtual angiography and 5RM muscle strength testing, and he performs both the measurement and the interpretation in person.
Cardiorespiratory fitness is the strongest modifiable predictor of all-cause mortality identified to date. Heart health is not only ECG and blood values; vascular structure, exercise capacity, muscle strength, recovery ability and stress response are all part of it. Assoc. Prof. Dr. Akın Torun holds an academic post at Atlas University Faculty of Medicine, has published more than 20 peer-reviewed studies, and serves as a performance consultant to national teams and as a Süper Lig first-team physician, which is what turns a test result into an exercise prescription.
Early evaluation of personal cardiovascular risk: family history, lifestyle, biomarkers, cardiac function and advanced imaging (including virtual angiography) interpreted together to reveal priority risk areas before they become an event, where a standard check-up relies on a stress test that does not visualise the coronary arteries.
A 6-week programme combining cardiology examination, ECG and ECHO, HRV, detailed bloods, virtual angiography and 5RM strength testing. VO2 max is measured breath by breath by CPET, not estimated by a wearable, and progress is followed with weekly specialist reviews.
12 or 24 sessions of individually supervised cardiac rehabilitation over 12 weeks, delivered one to one by a sports cardiologist. Used both to manage an existing cardiac condition and to prevent one, and internationally recognised as the most effective structured approach to cardiac recovery.
SOURCE: Mandsager K et al. ‘Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing’, JAMA Network Open 2018, PMC6324439 | European Society of Cardiology, escardio.org
Want to know your VO2 max?
Clinical nutrition at Dr. Terziler is led by Spec. Diet. Orçun Kürüm, the first dietitian in Turkey certified by the International Society of Sports Nutrition (ISSN). Nutrition is the bridge that converts every clinical finding, from Biomap 360° bloodwork and the microbiome to VO2 max, into a daily protocol, and progress is tracked with Visbody 3D body composition analysis rather than scale weight.
A longevity plan that is never translated into what a patient eats each day stays a report. Spec. Diet. Orçun Kürüm holds an MSc in Exercise and Nutrition Science from the University of Chester, managed the sports nutrition unit at Liv Hospital, and serves as R&D director for the Visbody 3D analysis system. Every programme opens with objective measurement and closes with a comparative outcome report, so change is documented rather than described.
A programme targeting metabolic balance, waist circumference, energy, sleep quality and body composition. Built from the patient’s own bloodwork, microbiome and hormonal data rather than a generic template, and adjusted as markers shift, with a 1-month applied follow-up in the CORE and PREMIUM tiers.
A programme for active individuals aged 35 to 65 building muscle mass, improving performance and lowering injury risk. Includes sports physician consultation, pre and post-exercise nutrition, and creatine, protein, electrolyte and recovery assessment.
Visbody 3D body composition analysis measuring visceral fat, muscle-to-fat ratio, posture and symmetry, repeated at the start and end of each programme. In a study of 139,691 adults across 17 countries, grip strength predicted mortality more strongly than systolic blood pressure.
SOURCE: Leong DP et al. ‘Prognostic value of grip strength: findings from the PURE study’, The Lancet 2015 | International Society of Sports Nutrition, sportsnutritionsociety.org
Want your body composition measured?
Dr. Terziler’s anti-aging IV protocols, including NAD+ therapy, ozone therapy and glutathione, alpha-lipoic acid and Vitamin C, are used as physician-guided support within the Longevity Reset, addressing biological aging at the metabolic and cellular level. NAD+ levels decline approximately 50% between ages 40 and 60, and IV replenishment restores mitochondrial function and sirtuin activation. All protocols are physician-supervised at the AACI-accredited clinic, led by Dr. Kürşat Yalvaç.
Advanced IV regeneration combining the Golden Vial and Copper Peptide support. Activates the body’s natural recovery mechanisms and targets cellular repair against stress, toxin load, fatigue and environmental damage.
Premium cellular revitalisation combining ozone therapy, alpha-lipoic acid, glutathione, Vitamin C and a high-potency vitamin complex. Reduces oxidative stress, strengthens cellular defence and increases regeneration capacity.
Cellular detox and renewal combining NAD+, ozone therapy, glutathione and Vitamin C. NAD+ levels decline approximately 50% between ages 40 and 60, and this protocol directly addresses that deficit.
SOURCE: Yoshino J et al. ‘NAD+ Intermediates’, Cell Metabolism 2018 | ISCO3 (International Scientific Committee of Ozone Therapy), isco3.org
Not sure which IV protocol fits?
Dr. Terziler offers physician-supervised men’s sexual health treatments in Istanbul led by Prof. Dr. Murat Zor, including ESWT + SVF + Exosome + P-Shot regenerative protocols, 3-piece penile prosthesis for advanced erectile dysfunction, and minimally invasive filler procedures. All treatments are planned individually with strict confidentiality.
3-Piece Penile Prosthesis: a high-level permanent solution for advanced erectile dysfunction, providing natural appearance, high comfort and strong permanent performance, with personalised surgical planning by Prof. Dr. Murat Zor.
ESWT + SVF + Exosome + P-Shot: a synergistic regenerative protocol targeting circulation, tissue quality, erectile capacity and performance, designed for stronger results, increased endurance and natural rejuvenation.
Glans and shaft filler: a minimally invasive procedure for aesthetic appearance and volume, with individual planning, natural results and quick return to daily life.
SOURCE: ISAPS Global Statistics on Men’s Aesthetic Procedures, isaps.org | ISSM (International Society for Sexual Medicine), issm.info
Need private guidance before choosing?
Dr. Terziler offers women’s sexual health treatments in Istanbul led by Dr. Emrah Kızıldağ, including Full Genital Rejuvenation, Vaginal Rejuvenation and Barbie Aesthetics. Both surgical and non-surgical approaches are available, planned with personalised protocols and strict confidentiality.
Comprehensive aesthetic and functional renewal for the female genital area, reshaping external appearance, supporting tissue quality and increasing comfort, delivered together in a personalised package designed to individual anatomy.
Regenerative solutions for changes caused by childbirth, aging or structural factors. Focuses on supporting vaginal tissue, increasing elasticity, balancing sensitivity and improving daily comfort. Surgical and non-surgical approaches available.
For women seeking a more aesthetic, well-groomed and symmetrical external appearance with minimal intervention, using a modern approach that preserves natural anatomy.
Want a discreet plan first?
Dr. Terziler’s skin rejuvenation protocols, led by Dr. Kürşat Yalvaç, use Morpheus8 RF microneedling, exosome therapy, copper peptide (GHK-Cu) treatment and LUMECCA IPL in 3-session packages. Morpheus8 stimulates collagen via fractional radiofrequency energy, exosome therapy strengthens cellular repair from within, and protocols are designed for measurable, lasting results.
3 sessions Morpheus8 + 3 sessions exosome therapy. Morpheus8 stimulates collagen via fractional RF energy, exosome therapy strengthens cellular repair, for tighter, more vibrant skin with multi-layered renewal.
3 sessions Morpheus8 + 3 sessions copper peptide therapy. Copper peptide (GHK-Cu) stimulates collagen and elastin synthesis while accelerating skin repair, for increased elasticity and visibly younger texture.
3 sessions LUMECCA Intense Pulsed Light + 3 sessions Salmon DNA therapy. LUMECCA targets redness, pigmentation and superficial capillaries, Salmon DNA supports cellular renewal, ideal for sun-damaged or uneven skin.
SOURCE: Pickart L & Margolina A. ‘Regenerative and Protective Actions of the GHK-Cu Peptide’, International Journal of Molecular Sciences 2018, PMC6073405
Final pricing depends on the tier you choose, START, CORE or PREMIUM, and on testing depth, in particular whether the programme includes epigenetic biological age testing and PRS, or full Whole Genome Sequencing. Because each plan is confirmed after a medical assessment, the clinic gives you an exact quote for your chosen tier within 24 hours of a free assessment, with no commitment.
| Region | Typical longevity programme cost | Physician-interpreted |
|---|---|---|
| Turkey (Dr. Terziler, Istanbul) | 60–70% less than US/UK equivalents | Yes, every patient examined in person |
| United Kingdom | £10,000–£25,000 | Varies by clinic |
| United States | $15,000–$50,000 for WGS-based protocols | Varies by clinic |
Want an exact quote for your tier?
Dr. Terziler Exclusive Clinic in Istanbul is an AACI-accredited clinic integrating longevity medicine, cardiology and performance medicine, clinical nutrition, medical aesthetics and sexual health under one roof, where every patient is examined in person by the relevant specialist. Built on more than 25 years of clinical experience and a longevity team of named physicians, it holds international health tourism accreditation and operates a USA office in Moorestown, NJ.
Years of clinical experience
Accredited clinical standards
Longevity Reset tiers
Organ systems aged epigenetically
Want the right RESET pathway?
Hair loss accelerates perceived aging by an average of 5 to 10 years. Dr. Terziler offers the most advanced hair transplant techniques available globally, including Picasso Robotic DHI, a system invented by Dr. Servet Terziler himself and unavailable at any other clinic worldwide.
Dr. Terziler offers three hair transplant techniques: Picasso Robotic DHI, Robotic DHI and Manual DHI. Dr. Servet Terziler invented the Robotic DHI machine itself, making him the only surgeon in the world who built the system he operates. Known as the Picasso of Hair, he takes part in every stage from hairline drawing to graft placement.
Invented by Dr. Servet Terziler. Combines robotic precision with DHI and the aesthetic expertise of the Picasso of Hair. Grafts placed at the correct angle, direction and density. Available for men and women.
Advanced hair transplant using robotic-assisted DHI precision invented by Dr. Servet Terziler. Natural hairline, ideal density, scarless application, minimal recovery and high patient satisfaction.
High-precision DHI using the Choi implanter pen. No channel-opening stage, which minimises time follicles spend outside the body, preserving graft vitality and achieving a higher retention rate.
SOURCE: ISHRS (International Society of Hair Restoration Surgery), ishrs.org
Want a hair plan that fits your biology?
Dr. Terziler’s hair loss treatment protocols combine Mega Exosome, PRP (platelet-rich plasma) and Copper Peptide (GHK-Cu) in 3-session packages. Exosome therapy renews follicles at the cellular level, PRP activates follicles using the patient’s own growth factors, and copper peptide stimulates thickening and healthy growth. These protocols work both standalone and to strengthen results before or after transplant.
3 sessions Mega Exosome + 3 sessions Copper Peptide + 3 sessions PRP. Multi-layered cellular repair, follicle stimulation and growth factor activation, for thinning, weak structure, shedding and loss of density.
3 sessions Mega Exosome + 3 sessions PRP. Exosome therapy renews follicles at the cellular level, PRP reduces shedding and increases hair strand quality, for a denser, stronger, more vibrant result.
SOURCE: Alves R & Grimalt R. ‘A Review of Platelet-Rich Plasma’, Skin Appendage Disorders 2018, PMC5945555
MEDICALLY REVIEWED BY
Dr. Terziler Clinical Team
Updated and medically reviewed: September 2026
Located in Etiler, Istanbul, Turkey, Dr. Terziler Exclusive Clinic is an AACI-accredited longevity, cardiology and performance medicine, clinical nutrition, sexual health, medical aesthetics and hair restoration center. Founded by Dr. Servet Terziler, the clinic delivers physician-led Longevity Reset programmes built on Biomap 360° biomarker profiling, epigenetic biological age testing and cardiopulmonary performance testing, where every patient is examined in person, for international patients from over 40 countries.
The best longevity clinic in Turkey should be judged by evidence, not by a ranking claim: physician-led interpretation where every patient is examined in person, AACI accreditation, epigenetic biological age testing, VO2 max by CPET, Biomap 360° biomarker profiling and a documented follow-up. Dr. Terziler Exclusive Clinic in Istanbul delivers all of these, with the Longevity Reset offered in three tiers, START, CORE and PREMIUM.
The Longevity Reset at Dr. Terziler Exclusive Clinic is a physician-supervised longevity programme in Istanbul offered in three tiers, START, CORE and PREMIUM. It combines Biomap 360° bloodwork, VO2 max by CPET, HRV, Visbody body composition, 10-day CGM and, from CORE upward, epigenetic biological age and genetic risk (PRS, and full Whole Genome Sequencing at PREMIUM). The full process runs about three months with a 12-week follow-up, on-site and online.
START is the functional foundation: Biomap 360° bloodwork, VO2 max, HRV, Visbody, 10-day CGM, ECHO/ECG and cardiac assessment. CORE adds epigenetic biological aging rate, microbiome analysis, a medical-aesthetic skin assessment, a MultiPass Ozone session and PRS genetic risk. PREMIUM adds full epigenetic profiling (biological age, aging rate and 11-organ aging), PRS and/or Whole Genome Sequencing, a women’s or men’s sexual-health evaluation and Salmon DNA.
The full process runs over approximately three months. Initial testing is completed in a short Istanbul visit, and a 12-week follow-up assessment then documents measurable change, with Visbody 3D body composition compared at the start and end. Cardiac-focused programmes such as Cardiology Reset run over 6 weeks, and cardiac rehabilitation over 12 weeks.
Longevity clinics are worth it when they offer physician-led, evidence-based protocols rather than device-based wellness packages. The most clinically valuable programmes include validated biomarker and biological age testing, functional measures such as VO2 max by CPET, and personalised interventions interpreted in person by a physician rather than generated by an algorithm.
Cardiorespiratory fitness, measured as VO2 max, is the strongest modifiable predictor of all-cause mortality identified to date. In a cohort of 122,007 patients undergoing exercise treadmill testing, higher cardiorespiratory fitness was associated with progressively lower mortality with no observed upper limit of benefit. At Dr. Terziler, VO2 max is measured by cardiopulmonary exercise testing under Assoc. Prof. Dr. Akın Torun.
VO2 max is the maximum volume of oxygen your body can use during intense exercise, expressed in millilitres per kilogram per minute. It reflects how efficiently the heart, lungs, blood and muscles work as one system. It matters for lifespan because it is one of the very few longevity markers that is both objectively measurable and directly trainable at any age. It is measured by cardiopulmonary exercise testing (CPET) with breath-by-breath gas analysis, not estimated by a smartwatch.
Biological age is measured most reliably through DNA methylation analysis of the epigenome. At Dr. Terziler it is reported as an overall biological age score, pace of aging (DunedinPACE methodology), organ-by-organ aging across 11 systems and telomere length, assessed system by system rather than as a single number. Functional markers including VO2 max, HRV, muscle strength and body composition are assessed alongside it.
Longevity medicine is a clinical specialty focused on extending healthspan, the number of years a person lives in full health, rather than treating disease after it occurs. It uses biomarker profiling, biological age assessment, metabolic analysis and preventive interventions to detect and reduce disease risk before symptoms appear. It differs from conventional medicine, which treats disease reactively.
Biological age testing measures how old your body’s cells actually are, which can differ significantly from your chronological age. The most clinically reliable method is epigenome methylation analysis, which examines DNA methylation patterns to estimate the biological age of individual organs. At Dr. Terziler, biological age is assessed organ by organ across 11 systems, not as a single number, and interpreted by a physician.
NAD+ is a coenzyme present in every cell and essential for energy production, DNA repair and sirtuin activation, proteins directly linked to the biological ageing rate. NAD+ levels decline approximately 50% between ages 40 and 60. IV NAD+ therapy delivers therapeutic-level replenishment that oral supplements cannot match due to poor bioavailability, and at Dr. Terziler it is used as physician-guided support within the Longevity Reset rather than as a standalone wellness drip.
Istanbul offers physician-supervised longevity programmes at 60 to 70% less cost than equivalent clinics in the US or UK, without reducing testing depth or interpretation. Dr. Terziler Exclusive Clinic is AACI-accredited, examines every patient in person, and offers the Longevity Reset in three tiers up to full Whole Genome Sequencing. International patients complete initial testing in a short Istanbul visit.
Dr. Terziler examines every patient in person and reads results in network context: Biomap 360° bloodwork, VO2 max by CPET, epigenetic organ-by-organ biological age, and PRS or full Whole Genome Sequencing, interpreted by named specialists rather than a report generator. It is AACI-accredited, integrates cardiology, performance medicine, nutrition, sexual health and medical aesthetics under one roof, and supports the plan with physician-guided therapies such as NAD+, ozone, peptide, exosome and hormone support.
Yes. Cardiac assessment is a core component of the Longevity Reset and is led by Assoc. Prof. Dr. Akın Torun, Associate Professor of Cardiology and a specialist in sports cardiology and performance medicine. It includes examination, ECG, echocardiography, HRV analysis, a full blood panel, VO2 max measurement by CPET and 5RM muscle strength testing. Very few longevity clinics integrate interventional cardiology and performance medicine into the same programme.
Yes. The CORE and PREMIUM tiers include dietitian assessment plus a one-month applied nutrition follow-up, led by Spec. Diet. Orçun Kürüm, the first dietitian in Turkey certified by the International Society of Sports Nutrition. Nutrition protocols are built from the patient’s own bloodwork, microbiome, hormonal and body composition data, and progress is tracked with Visbody 3D body composition analysis at the start and end of each programme.
Verify the clinic’s accreditation route (AACI), confirm which named physician interprets your results and whether you are examined in person, ask whether VO2 max is measured by CPET or estimated by a wearable, check what the follow-up includes, and confirm how progress is documented. Any clinic that cannot name the physician behind interpretation, or that relies on algorithm-generated reports, is operating below the standard the top tier requires.
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PROGRAMS